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Appendicitis score for children with suspected appendicitis. A randomized clinical trial
Hannu Lintula1, Hannu Kokki, Riikka Kettunen
1Department of Pediatric Surgery, Kuopio University Hospital, Kuopio, Finland. hannu.lintula@kuh.fi
Insights
Using an appendicitis score significantly improved diagnostic accuracy and reduced unnecessary appendicectomies in children. This clinical tool aids surgeons in making better decisions for suspected appendicitis cases.
Area of Science:
- Pediatric Surgery
- Diagnostic Accuracy
- Clinical Decision Support
Background:
- Appendicectomy is frequently performed without a definitive diagnosis.
- A validated diagnostic score for acute appendicitis in children has been previously developed.
Purpose of the Study:
- To evaluate if utilizing an appendicitis diagnostic score improves clinical outcomes in children with suspected appendicitis.
- To assess the impact of a diagnostic scoring system on surgical decision-making.
Main Methods:
- A prospective randomized study involving 126 children with suspected appendicitis.
- Children were assigned to either an appendicitis-score group or a no-score group.
- Surgical decisions were based on clinical assessment (no-score) versus the diagnostic score (appendicitis-score).
Main Results:
- The appendicitis-score group demonstrated significantly greater diagnostic accuracy (92% vs. 80%, P=0.04).
- The rate of unnecessary appendicectomies was significantly lower in the appendicitis-score group (17% vs. 29%, P=0.05).
- Higher sensitivity (100%) and specificity (88%) were observed in the appendicitis-score group.
Conclusions:
- The appendicitis score effectively reduces the rate of unnecessary appendicectomies in pediatric cases.
- Implementation of the appendicitis score enhances diagnostic precision for suspected appendicitis in children.
Background/Purpose:
Appendicectomy is often performed without certainty of diagnosis. We have previously constructed and validated a diagnostic score for acute appendicitis in children. The purpose of this prospective study was to determine whether diagnosis by using the appendicitis score may improve clinical outcomes for children with suspected appendicitis.
Methods:
A total of 126 children with suspected appendicitis were randomly assigned to either the appendicitis-score group or the no-score group. The attending general surgeon indicated a provisional diagnosis, a differential diagnosis and a provisional disposition on admission at 3 h and, if necessary, at 6, 9 and 12 h. The decision to operate was based on a clinical assessment in the no-score group and on the use of the diagnostic scoring system in the appendicitis-score group. The main outcome measures were the diagnostic accuracy (primary endpoint), the rate of unnecessary appendicectomies and adverse events between the two groups.
Results:
The diagnostic accuracy was significantly greater in the appendicitis-score group compared with that in the no-score group (92% vs 80%; P = 0.04). A significantly higher rate of unnecessary appendicectomies was observed in the no-score group compared with that in the appendicitis-score group (29% vs 17%; P = 0.05). In the appendicitis-score group, the sensitivity was 100%, specificity was 88%, positive predictive value was 83% and negative predictive value was 100%, compared to sensitivity of 96%, specificity of 67%, positive predictive value of 70% and negative predictive value of 96% observed in the no-score group. There were no differences in terms of the length of hospital stay, rate of complications and appendiceal histology between the two groups. The only case with missed appendicitis was in the no-score group.
Conclusion:
The use of the appendicitis score can reduce the unnecessary appendicectomy rate in general surgeons treating children with suspected appendicitis.
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