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Models of Health Promotion and Illness Prevention I01:25

Models of Health Promotion and Illness Prevention I

A model is a theoretical way to understand a concept or an idea. Models can overcome barriers to health regardless of diverse economic and cultural backgrounds. In addition, models make the task easier by providing different ways to approach complex issues. There are two major health promotion models: the health belief model and the health promotion model.
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
Models of Health Promotion and Illness Prevention II01:18

Models of Health Promotion and Illness Prevention II

The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results from...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...

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Related Experiment Video

Updated: Jun 29, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

A multi-type HPV transmission model.

Elamin H Elbasha1, Erik J Dasbach, Ralph P Insinga

  • 1Merck Research Laboratories, UG1C-60, PO Box 1000, North Wales, PA 19454-1099, USA. elamin_elbasha@merck.com

Bulletin of Mathematical Biology
|October 9, 2008
PubMed
Summary
This summary is machine-generated.

A quadrivalent Human papillomavirus (HPV) vaccine, approved in 2006, can significantly reduce HPV disease incidence and improve quality of life. Vaccination is cost-effective for females aged 12-24 and for combined male/female vaccination programs.

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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
13:41

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

Related Experiment Videos

Last Updated: Jun 29, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
13:41

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

Area of Science:

  • Epidemiology
  • Mathematical Modeling
  • Public Health

Background:

  • Genital Human papillomavirus (HPV) infection is a major cause of cervical cancer and warts.
  • A prophylactic quadrivalent HPV vaccine (types 6/11/16/18) was approved in the US in 2006.
  • Effective vaccination strategies are crucial for disease prevention and control.

Purpose of the Study:

  • To develop and utilize a mathematical model to assess HPV transmission dynamics.
  • To evaluate the epidemiologic consequences and cost-effectiveness of various HPV vaccination strategies.
  • To inform public health policy regarding HPV vaccine implementation in the United States.

Main Methods:

  • A nonlinear, deterministic, age-structured mathematical model was developed.
  • The model stratified the US population by gender and sexual activity.
  • Model inputs were derived from public data, literature, and clinical trial analyses.

Main Results:

  • The quadrivalent HPV vaccine can substantially reduce disease incidence.
  • Vaccination is projected to increase survival rates among females.
  • The vaccine improves quality of life for both males and females.
  • Cost-effectiveness was demonstrated for vaccinating females aged 12-24.
  • Combined vaccination strategies (early childhood and catch-up) were also found to be cost-effective.

Conclusions:

  • Prophylactic quadrivalent HPV vaccination offers significant public health benefits.
  • Targeted vaccination of females aged 12-24 is a cost-effective strategy.
  • Comprehensive vaccination programs including males and females are highly effective and cost-effective.