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Updated: Jun 29, 2026
07:54
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Peritoneal mesothelioma.
Mary E Hesdorffer1, John Chabot, Carolyn DeRosa
1Mesothelioma Applied Research Foundation, Santa Barbara, CA, USA. mhesdorer@curemeso.org
Current Treatment Options in Oncology
|October 9, 2008
Summary
Malignant peritoneal mesothelioma (MPM) is aggressive. Intensive loco-regional treatment, including cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), shows promise for prolonged survival in selected patients.
Area of Science:
- Oncology
- Surgical Oncology
- Medical Oncology
Background:
- Malignant peritoneal mesothelioma (MPM) is a rare and aggressive abdominal cancer.
- Current treatments for MPM are often unsatisfactory, necessitating novel therapeutic strategies.
- Loco-regional treatment approaches are emerging as potential improvements in patient outcomes.
Purpose of the Study:
- To evaluate the efficacy of an intensive multimodality treatment strategy for malignant peritoneal mesothelioma.
- To highlight the potential of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in managing MPM.
- To report observed prolonged survival in selected MPM patients undergoing aggressive treatment.
Main Methods:
- The described intensive treatment involved initial laparotomy with omentectomy and peritoneal implant resection.
- Repeated courses of intraperitoneal chemotherapy (doxorubicin, cisplatin, interferon gamma) were administered.
- Treatment concluded with second-look laparotomy, intraoperative hyperthermic perfusion (mitomycin, cisplatin), and whole abdominal radiation.
Main Results:
- Selected patients demonstrated prolonged survival following the intensive multimodality treatment.
- The combination of CRS and HIPEC is associated with improved survival in MPM.
- This intensive approach represents a departure from standard pemetrexed and cisplatin regimens.
Conclusions:
- Intensive loco-regional treatment strategies, including CRS and HIPEC, offer a promising avenue for managing malignant peritoneal mesothelioma.
- Careful patient selection is crucial for optimizing outcomes with aggressive multimodality therapy.
- Further research and specialized centers are vital for advancing MPM treatment.
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