Related Experiment Video
Updated: Jun 29, 2026
Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
[Increased risk of neoplasia among relatives of glioma patients]
A González-Aguilar1, P Gutiérrez-Castrellón, E Briceño
1Departamento de Neurogenética y Biología Molecular, Instituto Nacional de Neurologíay Neurocirugía Manuel Velasco Suárez, México DF, México.
Introduction:
Some previous studies have suggested familial aggregation of gliomas, although the results have not always been replicated.
Subjects And Methods:
In the present study of a Mexican population, we compared 100 cases of glioma with 124 healthy unrelated controls, as well as their 1st, 2nd and 3rd degree relatives (n = 3,575 and 4,520 respectively).
Results:
The relatives of the cases had a significantly higher risk of developing brain tumors than the relatives of controls (OR = 5.3; p < 0.05; 95% CI = 1.1-25.7), and their risk of developing any cancer was also increased (OR = 2; p < 0.05; 95% CI = 1.16-3.51), this risk was twofold for men when compared to females (OR = 2; p < 0.05; 95% CI = 1.15-3.37).
Conclusion:
The present study supports familial aggregation of brain tumors and warrants further research into their genetic etiology.
Related Concept Videos
02:59Cancer Prevention
Some...
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:33Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...