Related Experiment Video
Updated: Jun 29, 2026
14:23
A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
[DC-SIGNR polymorphisms and its association with HIV-1 infection]
Hui Wang1, Chunhui Wang, Tiejian Feng
1Laboratory of AIDS Research, Shenzhen Municipal Hospital of Infectious Diseases, Shenzhen, Guangdong 518020, P.R. China.
Summary
Genetic variations in the DC-SIGNR gene were studied for HIV-1 susceptibility. A specific genotype (9/5) was identified as a potential risk factor for HIV-1 infection in the Chinese Han population.
Area of Science:
- Immunogenetics
- Virology
- Population Genetics
Context:
- Dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin related (DC-SIGNR) plays a role in immune responses.
- Genetic polymorphisms in immune-related genes can influence susceptibility to infectious diseases like HIV-1.
- Understanding population-specific genetic factors is crucial for disease prevention strategies.
Purpose:
- To investigate the association between DC-SIGNR gene polymorphisms, specifically in the tandem repeat region, and susceptibility to Human Immunodeficiency Virus type 1 (HIV-1) infection.
- To compare the distribution of DC-SIGNR variants between HIV-1 seropositive and high-risk seronegative individuals within a Chinese Han cohort.
- To identify potential genetic risk factors for HIV-1 infection in the studied population.
Summary:
- The study analyzed 14 genotypes and 5 alleles of the DC-SIGNR gene in 345 HIV-1 seropositive and 468 high-risk seronegative individuals.
- The common DC-SIGNR allele 7 was more frequent in the Chinese Han population (67.1%) compared to Caucasians (46.0%).
- HIV-1 seropositive individuals showed a lower frequency of genotype 7/7 and a higher frequency of genotype 9/5 compared to seronegative controls.
Impact:
- The findings reveal unique genetic characteristics of DC-SIGNR tandem-repeat polymorphisms in the Chinese Han population.
- Genotype 9/5 of the DC-SIGNR gene is suggested as a potential risk factor for HIV-1 infection in this population.
- This research contributes to understanding the genetic basis of HIV-1 susceptibility and may inform targeted prevention efforts.
Related Concept Videos
01:05Single Nucleotide Polymorphisms-SNPs
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:25Immunodeficiency Diseases
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
There are three main causes of immunodeficiency disorders...