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Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
[Formulation optimization of panax notoginsenoside orally fast disintegration tablets]
1Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Summary
This study optimized Panax notoginsenoside orally fast-disintegrating tablets using a polynomial regression algorithm. The optimized formulation demonstrated satisfactory disintegration time, tensile strength, and taste.
Area of Science:
- Pharmaceutical Sciences
- Formulation Development
- Drug Delivery Systems
Background:
- Panax notoginsenoside is a key component in traditional medicine.
- Developing orally fast-disintegrating tablets (OFDTs) improves patient compliance and drug absorption.
- Optimization of OFDT formulations is crucial for efficacy and stability.
Purpose of the Study:
- To optimize the formulation of Panax notoginsenoside orally fast-disintegrating tablets.
- To establish optimal formulation and process parameters for Panax notoginsenoside OFDTs.
- To ensure satisfactory disintegration time, tensile strength, and palatability.
Main Methods:
- Utilized mannitol, microcrystalline cellulose (PH 102), and lactose 80 as diluents.
- Employed a polynomial regression algorithm to analyze relationships between compacting pressure, diluent ratio, disintegration time, and tensile strength.
- Used contour plots to determine optimal formulation and process parameters by contrasting tensile strength and disintegration time.
Main Results:
- Achieved optimal formulation and process parameters for Panax notoginsenoside OFDTs.
- The developed tablets exhibited favorable disintegration times and tensile strength.
- The taste of the Panax notoginsenoside OFDTs was found to be satisfactory.
Conclusions:
- The designed Panax notoginsenoside oral disintegrating tablets met the formulation objectives.
- The employed optimization method is effective for formulation screening of OFDTs.
- This approach provides a reliable strategy for developing improved drug delivery systems.
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