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Bacterial homologue of human blood group A transferase
Wen Yi1, Jie Shen, Guangyan Zhou
1Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Abstract:
A bacterial version of human blood group A transferase was identified and found to be able to accept five naturally existing H-antigen core structures as good substrates, demonstrating its versatility for synthesis of blood group A antigens. Furthermore, this enzyme was applied in the engineering of bacterial cell surface polysaccharides by remodeling blood group B mimicry into blood group A mimicry.
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