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Updated: Jun 29, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Enyne cross-metathesis with strained, geminally-substituted alkenes: direct access to highly substituted 1,3-dienes
Daniel A Clark1, Brenda S Basile, William S Karnofel
1Department of Chemistry, University at Buffalo, The State University of New York, Amherst, New York 14260, USA.
Abstract:
Angle strain in methylene cyclobutane was used to drive a cross-enyne metathesis with 1-alkynes, giving 1,1,3-trisubstituted 1,3-dienes in good isolated yields. An extensive survey of Grubbs' second-generation catalysts led to an optimized reaction conducted at 0 degrees C.
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