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Strychnine antagonizes jaw-closer motoneuron IPSPs induced by reticular stimulation during active sleep
S S Chirwa1, I Stafford-Segert, P J Soja
1Department of Physiology, University of California, Los Angeles 90024.
Brain Research
|May 3, 1991
Abstract:
In chronic, unanesthetized, normally respiring cats, stimulation of the nucleus reticularis pontis oralis induced inhibitory postsynaptic potentials (IPSPs) in masseter motoneurons during active sleep, but not during wakefulness or quiet sleep. Strychnine, when applied juxtacellularly by microiontophoresis to masseter motoneurons, specifically suppressed the active sleep-dependent IPSPs. In contrast, bicuculline did not suppress the active sleep-dependent IPSPs. These results indicate these IPSPs are mediated by the putative neurotransmitter glycine.