Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

Overview
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
Cholinergic Receptors: Muscarinic01:25

Cholinergic Receptors: Muscarinic

The pharmacological actions of acetylcholine are elicited via its binding to two families of cholinergic receptors or cholinoceptors, namely, muscarinic and nicotinic receptors. Muscarinic receptors are G protein-coupled receptors and have five subtypes, M1–M5. All mAChR subtypes are activated by acetylcholine and blocked by the antagonist, atropine. 
The subtypes M1, M3, and M5 couple with the Gq subunit and activate the phospholipase C (PLC) activity, mobilizing intracellular Ca2+. Activation...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What is the Functional Role of Obturator Externus Muscle? The Case of a Moderate Tear in a Professional Soccer Player: A Case Report.

Malaysian orthopaedic journal·2026
Same author

Arthroscopic debridement with microfragmented adipose tissue for wrist and hand chondral lesions in professional athletes.

Hand surgery & rehabilitation·2026
Same author

Impact of phytogenic additive and sodium monensin on broiler gut microbiota and immune response to Eimeria infection.

Research in veterinary science·2025
Same author

Transtibial versus anteromedial transportal femoral tunnel in single-bundle anterior cruciate ligament reconstruction: a systematic review and meta-analysis of prospective randomized controlled trials.

Musculoskeletal surgery·2024
Same author

MRI-derived radiomics to guide post-operative management of glioblastoma: Implication for personalized radiation treatment volume delineation.

Frontiers in medicine·2023
Same author

Editorial: Surgical approaches for the treatment of glioma.

Frontiers in oncology·2022

Related Experiment Video

Updated: Jun 29, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Mast cells and chemokines.

G S Katsanos, A Anogeianaki, C Orso

    Journal of Biological Regulators and Homeostatic Agents
    |October 10, 2008
    PubMed
    Summary

    Chemokines, small immune proteins, recruit cells and are key in inflammation. Neutralizing them may reduce inflammatory diseases and protect against allergies.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Chemokines are small secreted proteins crucial for immune cell function and recruitment.
    • Classified into CC, CXC, and CX3C families, they differentially attract immune cells like neutrophils and monocytes.
    • Mast cells, vital in allergic and inflammatory responses, are influenced by chemokines.

    Discussion:

    • Mast cell activation triggers the release of various cytokines/chemokines, including TNF-alpha, MIP-1, and CXCL8.
    • These mediators, alongside proteases and histamine, contribute to inflammatory processes.
    • Chemokine signaling plays a significant role in modulating immune cell behavior.

    Key Insights:

    • Chemokines orchestrate immune cell trafficking and inflammatory responses.
    • Mast cell activation is a central event in chemokine-mediated inflammation.

    More Related Videos

    Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
    10:39

    Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

    Published on: April 16, 2019

    Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
    11:31

    Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

    Published on: July 4, 2018

    Related Experiment Videos

    Last Updated: Jun 29, 2026

    Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
    16:01

    Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

    Published on: January 26, 2015

    Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
    10:39

    Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

    Published on: April 16, 2019

    Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
    11:31

    Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

    Published on: July 4, 2018

  • Specific chemokine families target distinct immune cell populations.

    • Outlook:

    • Targeting chemokines offers a potential therapeutic strategy for inflammatory and allergic diseases.
    • Further research into chemokine neutralization could lead to treatments for conditions like toxic shock syndrome.
    • Understanding chemokine pathways is essential for developing novel immunomodulatory therapies.