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Primary peritonitis due to Streptococcus pyogenes with reduced susceptibility to fluoroquinolones

Alexandra Doloy1, Claire Godin, Jean-Winoc Decousser

  • 1Microbiologie, Centre Hospitalier de Versailles, Le Chesnay 78157, France.

Diagnostic Microbiology and Infectious Disease
|October 10, 2008
PubMed

Insights

This study details the first reported case of primary peritonitis caused by Streptococcus pyogenes with decreased fluoroquinolone susceptibility. The infection led to treatment failure, highlighting a concerning antimicrobial resistance trend.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genetics

Background:

  • Primary peritonitis is a serious infection, typically caused by bacterial translocation.
  • Streptococcus pyogenes is a known pathogen, but rarely causes primary peritonitis.

Purpose of the Study:

  • To report the first case of primary peritonitis due to fluoroquinolone-resistant Streptococcus pyogenes.
  • To investigate the genetic basis of fluoroquinolone resistance in the causative strain.

Main Methods:

  • Clinical case reporting.
  • Microbiological culture and identification of Streptococcus pyogenes.
  • Antimicrobial susceptibility testing, including fluoroquinolones.
  • DNA sequencing of gyrA and parC genes.

Main Results:

  • A healthy woman developed primary peritonitis caused by Streptococcus pyogenes.
  • The isolate exhibited reduced susceptibility to fluoroquinolones.
  • Clinical and microbiological treatment failure occurred.
  • DNA sequencing identified three specific substitutions in the ParC protein (Ser80Pro, Asp91Asn, Ser140Pro).

Conclusions:

  • This case represents the first instance of primary peritonitis caused by Streptococcus pyogenes with reduced fluoroquinolone susceptibility.
  • The identified genetic mutations in ParC are associated with fluoroquinolone resistance.
  • This finding underscores the emerging threat of antimicrobial resistance in Streptococcus pyogenes infections.

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