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Published on: July 17, 2018
Gender difference among smoking, adiponectin, and high-sensitivity C-reactive protein
Tiina M Ahonen1, Hannu J Kautiainen, Sirkka M Keinänen-Kiukaanniemi
1Palokka Health Centre, Central Hospital of Middle Finland, Jyväskylä, Finland. tiina.ahonen@fimnet.fi
American Journal of Preventive Medicine
|October 10, 2008
Summary
Smoking impacts subclinical inflammation differently in men and women. In women, smoking is linked to lower adiponectin levels, while in men, it
Area of Science:
- Cardiovascular Health
- Metabolic Health
- Inflammation Research
Background:
- Subclinical inflammation is a key risk factor for cardiovascular diseases and type 2 diabetes.
- Adiponectin levels inversely correlate with insulin resistance.
- High-sensitivity C-reactive protein (hs-CRP) elevation predicts cardiovascular events.
- Smoking is associated with inflammatory markers, with potential gender-specific effects.
Purpose of the Study:
- To investigate the associations between adiponectin, hs-CRP, and smoking.
- To explore potential gender differences in these relationships.
Main Methods:
- Study included 365 men and 476 nondiabetic, middle-aged individuals.
- Smokers were defined as daily smoking subjects.
- Plasma adiponectin and hs-CRP levels were measured.
- Data collected in 1997-1998, with cytokine analysis in 2003.
Main Results:
- Women smokers had significantly lower adiponectin than nonsmokers (p=0.0017), persisting after adjustments.
- Men smokers had significantly higher hs-CRP than nonsmokers (p=0.018), persisting after adjustments.
- No significant differences in adiponectin were found in men, nor in hs-CRP in women smokers versus nonsmokers.
Conclusions:
- Smoking exhibits distinct associations with subclinical inflammation markers between genders in a nondiabetic population.
- Lower adiponectin levels in female smokers and higher hs-CRP levels in male smokers indicate gender-specific inflammatory responses to smoking.
