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Intracellular dCTP/ara-CTP ratio and the cytotoxic effect of ara-C
H Kawasaki1, H Kuwabara, H Hori
1Department of Pediatrics, Mie University School of Medicine, Japan.
Cancer Investigation
|January 1, 1991
Abstract:
In this study, the relationship between the dCTP/ara-CTP ratio and the cytotoxic effect of cytosine arabinoside (ara-C) was investigated. Intracellular levels of dNTPs and ara-CTP were analyzed by high-performance liquid chromatography. Although doubling time and intracellular dCTP levels were different in each of the cells, there was a consistent relation between the intracellular dCTP/ara-CTP ratio and the cytotoxic concentration of ara-C. These data suggest that the intracellular dCTP/ara-CTP ratio is one of the important factors for considering the cytotoxic action of ara-C.