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Updated: Jun 29, 2026

Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy

Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy

Published on: August 22, 2018

A dynamic optical imaging phantom based on an array of semiconductor diodes.

Jeremy C Hebden¹, Teresa Correia, Imran Khakoo

¹Department of Medical Physics & Bioengineering, University College London, Gower Street, London WC1E 6BT, UK.

Physics in Medicine and Biology

|October 10, 2008

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A novel electrically-activated phantom was developed using semiconductor diodes and thermochromic dye to simulate moving optical absorption for diffuse optical imaging system evaluation. This phantom enables realistic testing of imaging technologies.

Area of Science:

Biomedical Optics
Optical Imaging
Phantom Development

Background:

Diffuse optical imaging (DOI) systems require accurate phantoms for evaluation.
Simulating dynamic optical properties in phantoms is challenging.

Purpose of the Study:

To design and present an electrically-activated phantom for diffuse optical imaging systems.
To simulate dynamic changes in optical absorption within a tissue-like medium.

Main Methods:

Utilized an array of semiconductor diodes to heat a thermochromic dye.
Embedded the dye within a polyester resin with tissue-like optical properties.
Sequentially addressed diodes to mimic moving optical absorption.

Main Results:

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Successfully designed and implemented two diode-array phantom configurations.
Presented imaging experiment results demonstrating the phantom's capability.
Validated the simulation of moving optical absorption.

Conclusions:

The developed electrically-activated phantom is effective for evaluating diffuse optical imaging systems.
This phantom provides a novel method for simulating dynamic optical absorption.
Further research can explore advanced applications of this phantom technology.