Related Experiment Video

Updated: Jun 29, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

Design and synthesis of intrinsically cell-penetrating nucleopeptides

Piero Geotti-Bianchini1, Julien Beyrath, Olivier Chaloin

  • 1CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunologie et Chimie Thérapeutiques, 15 Rue René Descartes, 67000, Strasbourg, France.

Organic & Biomolecular Chemistry
|October 10, 2008
PubMed

Abstract:

Nucleopeptides, which are constituted of alpha-amino acids bearing nucleobases at their side chains, are able to penetrate into cells and to reach the nucleus without cytotoxic effects.

More Related Videos

Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide
07:33

Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide

Published on: December 19, 2020

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions
10:26

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions

Published on: December 20, 2017

Related Experiment Videos

Last Updated: Jun 29, 2026

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
10:12

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide
07:33

Fluorescent Leakage Assay to Investigate Membrane Destabilization by Cell-Penetrating Peptide

Published on: December 19, 2020

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions
10:26

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions

Published on: December 20, 2017

Related Concept Videos

Peptidoglycan Synthesis01:28

Peptidoglycan Synthesis

Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan biosynthesis begins in...
Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...

Articles linked to this work by shared authors, journal, and citation graph.

Degradation of a graphene-reinforced polyamide by fungi: When culture conditions matter.

Journal of environmental sciences (China)·2026

3A Cyanide-Bridged Ru-Fe Supramolecular Photocatalyst for Efficient CO2 Reduction.

ChemSusChem·2026

Multifunctional Nanoplatforms for Endoplasmic Reticulum-Targeted Cancer Therapy.

ACS nano·2026

Neuropeptide Y-Graphene Oxide Complexes Inhibit Amygdala NPY-Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

A first-in-human study evaluating safety, PK, and PD of a novel universal anticoagulant reversal agent, OKL-1111.

Blood vessels, thrombosis & hemostasis·2026

Reactivity and mechanistic insights into multistep silane functionalization of oxo-graphene.

Nanoscale·2026

Visible-light-induced glycosyl radicals from diverse precursors for C-glycosylation.

Organic & biomolecular chemistry·2026

Electron-transfer-mediated generation and reactions of organopotassium species under flow coexistence conditions.

Organic & biomolecular chemistry·2026

Enantioselective Michael addition of N-substituted 3-chlorooxindoles with 1,1-bis(arylsulfonyl)ethylenes: access to 3,3-disubstituted and spirocyclopropane-fused oxindoles.

Organic & biomolecular chemistry·2026

Indole S-glycosides: from natural product discovery to chemical synthesis.

Organic & biomolecular chemistry·2026

The linear-paired electrochemical synthesis of unsymmetrical sulfides by an anodic initiated mitsunobu-type activation of alcohols combined with the cathodic activation of disulfides under neutral conditions.

Organic & biomolecular chemistry·2026

Base-controlled divergent oxidative dimerization of allomaltol-containing enolates: access to distinct diastereomers of 1,4-diketones.

Organic & biomolecular chemistry·2026

Phenolic Glycosides From Ficus erecta and Their Anti-Inflammatory and Neuroprotective Activities.

Chemistry & biodiversity·2026

Nose-to-brain delivery of IRX4204 by cell-adhesion peptide-functionalized gemini surfactant-phospholipid nanoparticles.

RSC pharmaceutics·2026

The characterization of a rhamnosylated triterpenic saponin from Quillaja saponaria Mol. reveals novel adjuvant, antibacterial, antiviral, antifungal and antiproliferative properties.

Frontiers in pharmacology·2026

Reglid: novel glycolipids from Korean red ginseng marc.

Journal of ginseng research·2026

Ginseng polysaccharides: Structures-based classification and biological activities-A review.

Journal of ginseng research·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us