Related Experiment Video
Updated: Jun 29, 2026
![PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F57243.jpg&w=3840&q=50)
12:01
PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
Published on: June 14, 2018
Neuroimaging in ischemia and infarction.
Maxim D Hammer1, Lawrence R Wechsler
1The Stroke Institute, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA. hammermd@upmc.edu
Seminars in Neurology
|October 10, 2008
Summary
This study reviews neuroimaging for acute ischemic stroke, focusing on quantifying infarct extent, salvageable brain tissue, and identifying treatable arterial blockages using MRI and CT scans.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Acute ischemic stroke requires prompt diagnosis and management.
- Understanding cerebral blood flow is crucial for stroke pathophysiology.
- Current neuroimaging plays a vital role in acute stroke care.
Purpose of the Study:
- To provide an overview of clinical neuroimaging techniques for acute ischemic stroke.
- To compare methods for quantifying infarct extent and salvageable brain tissue.
- To highlight the importance of identifying treatable arterial stenosis or occlusion.
Main Methods:
- Review of magnetic resonance imaging (MRI) and computed tomography (CT) for infarct quantification.
- Detailed comparison of techniques for measuring cerebral blood flow (CBF) to assess tissue at risk.
- Illustration of methods for visualizing cerebral circulation.
Main Results:
- MRI and CT offer distinct approaches to quantifying infarction.
- Various techniques exist for measuring CBF, crucial for determining salvageable tissue.
- Imaging can identify arterial blockages amenable to intervention.
Conclusions:
- Effective neuroimaging in acute ischemic stroke aims to quantify infarct, assess salvageable tissue, and detect treatable vascular lesions.
- Comparison of MRI and CT methods provides guidance for clinical practice.
- Advanced imaging techniques are essential for optimizing stroke treatment decisions.
Related Concept Videos
01:14Brain Imaging
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:21Imaging Studies for Cardiovascular System IV: CMRI
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
01:19Imaging Studies VII: Vascular Imaging
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:24Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...