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Screening for Phytoestrogens using a Cell-based Estrogen Receptor β Reporter Assay
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Published on: June 7, 2020

Selective estrogen receptor modulators and phytoestrogens.

Tawakalitu Oseni1, Roshani Patel, Jennifer Pyle

  • 1Fox Chase Cancer Center, Philadelphia, PA 19111-2497, USA.

Planta Medica
|October 10, 2008
PubMed
Summary
This summary is machine-generated.

Selective estrogen receptor modulators (SERMs) like tamoxifen have revolutionized breast cancer treatment and prevention. Research is exploring natural SERMs, such as soy-derived phytoestrogens, for their potential protective effects.

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Published on: January 1, 2018

Area of Science:

  • Oncology
  • Endocrinology
  • Nutritional Science

Background:

  • Breast cancer treatment has been significantly advanced by targeted therapies, particularly those involving estrogen receptor (ER) pathways.
  • Synthetic selective estrogen receptor modulators (SERMs), such as tamoxifen and raloxifene, have proven effective in treating and preventing ER-positive breast cancer and osteoporosis.
  • Observed lower breast cancer incidence in Asian populations with soy-rich diets has spurred interest in phytoestrogens as natural SERMs.

Purpose of the Study:

  • To review the development and established roles of tamoxifen and raloxifene as key SERMs in breast cancer management.
  • To explore emerging research on phytoestrogens, their potential as natural SERMs, and their relationship to synthetic counterparts.
  • To address clinical questions regarding the efficacy of phytoestrogens in breast cancer prevention.

Main Methods:

  • Literature review of scientific achievements in breast cancer treatment and prevention over the last two decades.
  • Analysis of the role of estrogen, its receptor, and targeted therapies, including SERMs.
  • Examination of epidemiological data on breast cancer incidence related to diet, specifically soy consumption.
  • Review of studies on phytoestrogens and their comparison to synthetic SERMs.

Main Results:

  • Synthetic SERMs, tamoxifen and raloxifene, have saved numerous lives by enabling targeted treatment and prevention strategies for ER-positive breast cancer and osteoporosis.
  • Phytoestrogens, found in soy and other natural foods, are being investigated for their potential cancer-protective properties, drawing parallels to synthetic SERMs.
  • Clinical research is ongoing to understand the mechanisms and effectiveness of phytoestrogens in breast cancer prevention.

Conclusions:

  • Synthetic SERMs represent a major breakthrough in breast cancer therapy and prevention.
  • Phytoestrogens show promise as natural agents for breast cancer prevention, warranting further investigation into their mechanisms and clinical applications.
  • Understanding the similarities and differences between natural and synthetic SERMs is crucial for advancing breast cancer research and patient care.