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Related Experiment Video

Updated: Jun 29, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Interventions for treating depression after stroke.

Maree L Hackett1, Craig S Anderson, Allan House

  • 1Department of Neurological and Mental Health, George Institute for International Health, PO Box M201, Missenden Road, Sydney, NSW, Australia, 2050. mhackett@george.org.au

The Cochrane Database of Systematic Reviews
|October 10, 2008
PubMed
Summary
This summary is machine-generated.

Pharmacotherapy for post-stroke depression shows a small benefit but increases adverse events. Psychotherapy offers no proven benefit, and more research is needed for treatment recommendations.

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Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint
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Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Published on: January 9, 2026

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Last Updated: Jun 29, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint
06:45

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Published on: January 9, 2026

Area of Science:

  • Neurology
  • Psychiatry
  • Clinical Trials

Background:

  • Post-stroke depression is a common complication impacting patient recovery.
  • It is frequently underdiagnosed and inadequately treated.
  • This review is an update of previous Cochrane reviews on the topic.

Purpose of the Study:

  • To evaluate the effectiveness of pharmaceutical, psychological, and electroconvulsive treatments for depression in stroke patients.
  • To determine if these treatments improve patient outcomes.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials.
  • Searched multiple databases including Cochrane, MEDLINE, EMBASE, CINAHL, and PsycINFO.
  • Included trials comparing treatments for depression in stroke patients against placebo or standard care.

Main Results:

  • Sixteen trials involving 1655 participants were analyzed.
  • Pharmacotherapy demonstrated a modest benefit in reducing depressive symptoms and achieving remission.
  • Psychotherapy showed no evidence of benefit, and electroconvulsive therapy (ECT) trials were not identified.
  • Increased adverse events were associated with pharmacotherapy.

Conclusions:

  • Pharmacotherapy offers a small but significant effect on treating depression and reducing symptoms in stroke patients.
  • However, pharmacotherapy is linked to a significant increase in adverse events.
  • Further research is necessary to establish definitive treatment guidelines for post-stroke depression.