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Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Essential Minerals for Bone Health

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Related Experiment Video

Updated: Jun 29, 2026

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Bisphosphonate therapy for osteogenesis imperfecta.

Carrie A Phillipi¹, Tracey Remmington, Robert D Steiner

¹Pediatrics Department, Oregon Health & Science University, 707 SW Gaines Street, Portland, Oregon 97239-2901, USA. phillica@ohsu.edu

The Cochrane Database of Systematic Reviews

|October 10, 2008

Summary

This summary is machine-generated.

Bisphosphonates may increase bone mineral density (BMD) in osteogenesis imperfecta (OI) patients. However, evidence is insufficient to confirm fracture reduction or improved clinical function, necessitating further research.

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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

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Published on: December 10, 2010

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

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Published on: March 29, 2018

Area of Science:

Bone Metabolism and Genetics
Pharmacological Interventions
Pediatric and Adult Bone Diseases

Background:

Osteogenesis imperfecta (OI) is a genetic disorder affecting type I collagen, leading to frequent fractures.
Bisphosphonates are a therapeutic class utilized to mitigate fracture risk in OI patients.

Purpose of the Study:

To evaluate the efficacy and safety of bisphosphonates in OI.
To assess improvements in bone mineral density (BMD), fracture rates, and clinical function.

Main Methods:

Systematic review of randomized and quasi-randomized controlled trials.
Searched Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register, PubMed, and conference proceedings.
Data extraction and quality assessment by two independent authors.

Main Results:

Eight studies (403 participants) were included.
Oral bisphosphonates showed mixed results on fracture risk and BMD.
Intravenous bisphosphonates did not significantly reduce fracture incidence or increase BMD in aggregated data, though one trial showed improvements.
Limited data on growth, pain, and functional outcomes.

Conclusions:

Bisphosphonates appear to increase BMD in OI patients.
Evidence is inconclusive regarding fracture reduction and clinical function improvement.
Further research is needed to determine optimal bisphosphonate therapy and long-term safety.