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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

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Related Experiment Video

Updated: Jun 29, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Chuanxiong-type preparations for acute ischemic stroke.

Yong Yuan1, Xiaoxi Zeng, Yukun Luo

  • 1West China Medical Center, Sichuan University, No. 17, Ren Min Nan Lu 3 Duan, Chengdu, Sichuan, China, 610041.

The Cochrane Database of Systematic Reviews
|October 10, 2008
PubMed
Summary

Evidence on the efficacy of chuanxiong for acute ischemic stroke is limited. Two low-quality trials found insufficient data to support clinical recommendations for this stroke treatment.

Related Experiment Videos

Last Updated: Jun 29, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Area of Science:

  • Neurology
  • Traditional Chinese Medicine
  • Evidence-Based Medicine

Background:

  • Ischemic stroke is a leading cause of death and disability globally.
  • Chuanxiong is a traditional herb suggested for stroke treatment, but evidence is unclear.

Purpose of the Study:

  • To evaluate the safety and efficacy of chuanxiong in treating acute ischemic stroke.

Main Methods:

  • Comprehensive literature search across multiple databases (e.g., Cochrane, MEDLINE, EMBASE) and trial registers.
  • Inclusion of randomized controlled trials comparing chuanxiong with placebo or no treatment for acute ischemic stroke within 14 days of onset.
  • Independent selection, quality assessment, and data extraction by multiple reviewers.

Main Results:

  • Two low-quality randomized controlled trials with 161 participants were included.
  • Neither trial reported mortality rates or participant dependency.
  • Reliable evidence on the effectiveness of chuanxiong for acute ischemic stroke is currently unavailable.

Conclusions:

  • Insufficient evidence from the included poor-quality trials precludes clinical recommendations.
  • High-quality, well-designed randomized controlled trials are necessary to determine the efficacy and safety of chuanxiong for acute ischemic stroke.