Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Suctioning the Nasopharyngeal Airway

Suctioning the Nasopharyngeal Airway

Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required

Acute Respiratory Failure-V

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...

Inhaled Medications

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by anesthetizing...

Antiasthma Drugs: β2-Adrenoceptor Agonists

Antiasthma Drugs: β₂-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Transcriptomic Identification of Diagnostic Biomarkers for Alcohol-Associated Liver Cirrhosis: Integration of Population-Level Epidemiology with Multi-Cohort Transcriptomic Analysis.

International journal of molecular sciences·2026

Same author

Host-specific ubiquitination of prM orchestrates ESCRT recruitment to mediate efficient Japanese Encephalitis Virus assembly in vertebrates.

PLoS pathogens·2026

Same author

Fiber-integrated acousto-optic-modulator-based phase-controlled Rydberg atomic electrometer.

The Review of scientific instruments·2026

Same author

Reliable luciferase immunoprecipitation system assays for the detection of porcine reproductive and respiratory syndrome virus antibodies.

Veterinary journal (London, England : 1997)·2026

Same author

Integrative transcriptomic analysis uncovers the microRNA-centric regulation of Japanese encephalitis virus infection in porcine trophoblast cells.

Virulence·2026

Same author

A comprehensive CFD lifecycle dataset for marine vessel hydrodynamics.

Scientific data·2026

Search research articles

Related Experiment Video

Updated: Jun 29, 2026

Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield

Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield

Published on: March 24, 2014

Nebulized hypertonic saline solution for acute bronchiolitis in infants.

Linjie Zhang¹, Raúl A Mendoza-Sassi, Claire Wainwright

¹Department of Maternal and Child Health, Federal University of Rio Grande, Rua Visconde Paranaguá 102, Centro, Rio Grande, RS, Brazil, 96201-900. zhanglinjie63@yahoo.com.br

The Cochrane Database of Systematic Reviews

|October 10, 2008

Summary

Nebulized 3% saline significantly reduced hospital stays and improved clinical scores in infants with acute viral bronchiolitis. This treatment offers a safe and effective option for managing this common respiratory illness in infants.

More Related Videos

Intranasal Administration of CNS Therapeutics to Awake Mice

Intranasal Administration of CNS Therapeutics to Awake Mice

Published on: April 8, 2013

Related Experiment Videos

Last Updated: Jun 29, 2026

Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield

Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield

Published on: March 24, 2014

Intranasal Administration of CNS Therapeutics to Awake Mice

Intranasal Administration of CNS Therapeutics to Awake Mice

Published on: April 8, 2013

Area of Science:

Pediatric Respiratory Medicine
Critical Care
Evidence-Based Medicine

Background:

Acute viral bronchiolitis in infants is characterized by airway edema and mucus plugging.
Nebulized hypertonic saline solution shows potential in reducing these pathological changes and alleviating airway obstruction.

Purpose of the Study:

To evaluate the efficacy of nebulized hypertonic saline solution in treating infants diagnosed with acute viral bronchiolitis.

Main Methods:

Systematic review and meta-analysis of randomized controlled trials (RCTs) and quasi-RCTs.
Searched multiple databases including CENTRAL, MEDLINE, EMBASE, and LILACS.
Included studies involved infants up to 24 months with acute bronchiolitis treated with nebulized hypertonic saline.

Main Results:

Four trials with 254 infants were included.
Nebulized 3% saline significantly reduced mean hospital stay compared to 0.9% saline (MD -0.94 days, P = 0.0006).
The 3% saline group showed significantly lower clinical scores on days 1-3 and reported no adverse events.

Conclusions:

Nebulized 3% saline demonstrates significant benefits in reducing hospital stay duration for infants with acute viral bronchiolitis.
The treatment effectively improves clinical severity scores, with greater impact observed in outpatients.
Current evidence supports nebulized 3% saline as a safe and effective intervention for acute viral bronchiolitis in infants.