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Updated: Jun 29, 2026
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
[The clinical and laboratory features of 263 cases of chronic lymphocytic leukemia]
Zeng-Jun Li1, Lu-Gui Qiu, Tong Wu
1Institute of Hematology and Blood Diseases Hospital, CAMS, Tianjin 300020, China.
Insights
This study analyzed chronic lymphocytic leukemia (CLL) in 263 patients, noting common symptoms like fatigue and lymphadenopathy. Findings suggest unique clinical features compared to international data, highlighting the need for new prognostic markers.
Area of Science:
- Hematology
- Oncology
- Clinical Medicine
Context:
- Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy.
- Understanding the specific clinical and laboratory features of CLL is crucial for patient management.
- This study investigated CLL characteristics in a specific patient cohort.
Purpose:
- To analyze the clinical and laboratory features of chronic lymphocytic leukemia (CLL).
- To compare local findings with international data for CLL.
- To identify potential areas for further research in CLL prognosis and treatment.
Summary:
- Retrospective analysis of 263 CLL patients (median age 60, male/female ratio 2.17:1).
- Common symptoms included fatigue and lymphadenopathy; 35.4% were asymptomatic with low Rai grades.
- Laboratory findings revealed specific white blood cell counts, lymphocyte percentages, bone marrow infiltration patterns, and CD marker expressions (CD5, CD25).
- Hypogammaglobulinemia was frequent, while chromosomal abnormalities were rarely detected by routine examination.
- Observed clinical and laboratory characteristics differed from international data.
Impact:
- Provides insights into the specific presentation and characteristics of CLL in the studied population.
- Highlights potential differences in CLL epidemiology and clinical course compared to global data.
- Emphasizes the need for further research into novel biomarkers for improved prognosis and treatment selection in CLL.
Objective:
To analyze the clinical and laboratory features of chronic lymphocytic leukemia (CLL).
Methods:
Retrospective investigation of 263 patients with CLL in our hospital between Feb. 2000 and Jan. 2007.
Results:
The median age was 60 years with male/female ratio of 2.17 : 1. Patients who were asymptomatic at diagnosis (35.4%) had low Rai grades. Fatigue and lymphadenopathy (54.8%) were the most common features at presentation. Infections, connective tissue diseases and secondary tumors frequently occurred in CLL. WBC counts were between (10 - 100) x 10(9)/L, with lymphocytes percentages more than 0.50 in 97.1% patients. Bone marrow was normal- to hyper-cellularity with lymphocytes percentages more than 0.300 in 99.4% patients. Diffuse infiltrations in bone marrow section were found in 72.2% patients. There were lower CD5 (85.1%) and higher CD25 (78.9%) positivities in the present series as compared with that in other reports. Hypogammaglobulinemia, especially hypo-IgM, usually occurred. Chromosome abnormality were rarely found by routine chromosome examination.
Conclusions:
There were some clinical and laboratory characteristics different from that of abroad data. Further exploration of new markers is required for prognosis prediction and treatment choice.
