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Updated: Jun 29, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
[Association between estrogen receptor beta gene polymorphisms and Parkinson disease]
Rong-Jie Chen1, Ben-Shu Zhang, Shi-Min Wang
1Department of Neurology, General Hospital of Tianjin Medical University, Tianjin 300052, China. sue904crj@sohu.com
Objective:
To investigate the association between two estrogen receptor (ER) beta gene polymorphisms and Parkinson disease (PD) as well as Parkinson disease with dementia (PDD) in Chinese people.
Methods:
Peripheral blood samples were collected from 115 PD patients (including 26 PDD cases), 56 males and 55 females, aged 64 +/- 10, and 116 sex and age-matched healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to analyze the polymorphism of the fifth exon RsaI and the eighth exon AluI of ERbeta gene. Te relationship between each genotype or allele frequencies and PD/PDD was analyzed using chi-square test.
Results:
There was no difference in the polymorphism of ERbeta genes AluI and Rsa I between the PD group and control group and between the PDD group and control group (all P > 0.05).
Conclusion:
Genetic variations from AluI and RsaI digestion in ERbeta gene do not affect the risk of PD and PDD.
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