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Related Experiment Video

Updated: Jun 29, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

False-negative sentinel lymph node biopsy.

B J van Wely1, M L Smidt, I M de Kievit

  • 1Department of Surgery, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands. bobvanwely@yahoo.com

The British Journal of Surgery
|October 11, 2008
PubMed
Summary

False-negative sentinel lymph node (SLN) biopsy results in axillary recurrence, particularly with longer follow-up. This study found a 6.9% false-negative rate and identified factors influencing recurrence risk.

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Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • The clinical significance of false-negative axillary sentinel lymph node (SLN) biopsy remains unclear.
  • Establishing axillary recurrence rates and identifying prognostic factors are crucial for patient management.

Purpose of the Study:

  • To assess axillary recurrence and false-negative rates following SLN biopsy.
  • To identify prognostic factors for recurrence.
  • To monitor patient survival after SLN biopsy.

Main Methods:

  • Prospective analysis of SLN biopsy procedures (1998-2004).
  • Examination of retrieved nodes using H&E and immunohistochemical staining.
  • Adjuvant treatment based on Dutch guidelines; further surgery only for positive SLNs.

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Last Updated: Jun 29, 2026

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Main Results:

  • 11 of 392 patients (2.8%) with negative SLNB developed axillary recurrence after a median 65-month follow-up.
  • The false-negative rate was 6.9%.
  • Recurrence was more common in patients treated with simple mastectomy without radiation; no other prognostic factors were identified.

Conclusions:

  • Axillary recurrence and false-negative rates after SLN biopsy are associated with longer follow-up periods.
  • Early detection and appropriate management are essential for improving outcomes in breast cancer patients.