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Updated: Jun 29, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
Complicated skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus: epidemiology, risk
1Microbiology and Communicable Disease, Royal Hampshire County Hospital, Winchester, Hampshire, United Kingdom. matthew.dryden@wehct.nhs.uk
Background:
Complicated skin and soft tissue infections (cSSTIs) present a challenge to healthcare providers. Methicillin-resistant Staphylococcus aureus (MRSA) is an increasing cause of these infections, particularly in certain countries. Surgeons and other healthcare providers need to understand cSSTIs and manage them effectively.
Methods:
Review of the literature related to the pathogens associated with cSSTIs.
Results:
In the United States, MRSA is a major cause of cSSTIs, and toxin-producing community-acquired MRSA (CA-MRSA) strains are increasing in prevalence. These strains are distinct from hospital-acquired MRSA (HA-MRSA). Infection with novel CA-MRSA in previously healthy individuals has emerged as an important public health problem. The virulence of these pathogens and their increasing prevalence in cSSTIs indicate that patients may be at higher risk for complications.
Conclusions:
There is a growing prevalence of MRSA, particularly in cSSTIs observed in both the community and the hospital setting. Early appropriate recognition and treatment of cSSTIs may improve patient outcomes.
Insights
Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly causing complicated skin and soft tissue infections (cSSTIs). Early recognition and treatment of these MRSA-driven cSSTIs are crucial for better patient outcomes.
Area of Science:
- Infectious Diseases
- Dermatology
- Public Health
Background:
- Complicated skin and soft tissue infections (cSSTIs) pose a significant challenge for healthcare providers.
- Methicillin-resistant Staphylococcus aureus (MRSA) is a growing cause of cSSTIs globally.
- Understanding cSSTIs and MRSA is essential for effective clinical management.
Purpose of the Study:
- To review the literature on pathogens associated with cSSTIs.
- To highlight the increasing prevalence of MRSA in cSSTIs.
- To inform healthcare providers about the evolving landscape of cSSTIs.
Main Methods:
- Literature review focusing on pathogens implicated in cSSTIs.
- Analysis of current trends in MRSA prevalence.
- Examination of MRSA strain characteristics.
Main Results:
- MRSA is a primary pathogen in US cSSTIs.
- Toxin-producing community-acquired MRSA (CA-MRSA) strains are rising, distinct from hospital-acquired MRSA (HA-MRSA).
- Novel CA-MRSA infections in healthy individuals represent a public health concern, potentially increasing patient complication risks.
Conclusions:
- MRSA prevalence is increasing in both community and hospital-acquired cSSTIs.
- Prompt identification and treatment of cSSTIs can lead to improved patient outcomes.
- Awareness of evolving MRSA strains is critical for managing cSSTIs effectively.
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