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Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
Lessons for tuberculosis vaccines from respiratory virus infection
Peter Charles Leonard Beverley1, Elma Zaven Tchilian
1The University of Oxford, Nuffield Department of Clinical Medicine, Edward Jenner Institute for Vaccine Research, Compton, Berkshire, RG20 7NN, UK. peter.beverley@jenner.ac.uk
Abstract:
There is a worldwide epidemic of increasingly drug-resistant TB. Bacillus Calmette-Guérin vaccination provides partial protection against disseminated disease in infants but poor protection against later pulmonary TB. Cell-mediated protection against respiratory virus infections requires the presence of T cells in lung tissues, and the most effective prime-boost immunizations for Mycobacterium tuberculosis also induce lung-resident lymphocytes. These observations need to be taken into account when designing future vaccines against M. tuberculosis.
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