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Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

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Related Experiment Video

Updated: Jun 29, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Bilayered scaffolds for osteochondral tissue engineering.

Timothy M O'Shea¹, Xigeng Miao

¹School of Engineering Systems, Queensland University of Technology, Brisbane, Australia.

Tissue Engineering. Part B, Reviews

|October 11, 2008

Summary

This summary is machine-generated.

Osteoarthritis treatment can be advanced by osteochondral tissue engineering using bilayered scaffolds. This review explores current strategies and highlights the need for innovative materials science in scaffold design for better joint repair.

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Last Updated: Jun 29, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

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Published on: April 14, 2026

Layered Alginate Constructs: A Platform for Co-culture of Heterogeneous Cell Populations

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Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

Area of Science:

Biomaterials Science
Regenerative Medicine
Orthopedics

Background:

Osteoarthritis (OA) is a widespread degenerative joint disease with significant socioeconomic impact.
Current surgical treatments for OA are limited, highlighting the need for advanced regenerative strategies.
Osteochondral tissue engineering offers a promising approach to repair articular cartilage and subchondral bone, potentially slowing OA progression.

Purpose of the Study:

To review current bilayered scaffold strategies for osteochondral tissue engineering.
To emphasize the importance of materials science in developing effective osteochondral regeneration solutions.
To identify needs for innovative scaffold design and fabrication for improved clinical relevance.

Main Methods:

Review of existing literature on bilayered scaffolds for osteochondral tissue engineering.
Analysis of current strategies addressing the dual-tissue regeneration challenge.
Focus on materials science contributions and limitations in scaffold development.

Main Results:

Three primary bilayered scaffold strategies for osteochondral tissue engineering are currently employed.
Existing methods face challenges due to the distinct functional requirements of cartilage and subchondral bone.
Materials science plays a critical role in achieving integrated regeneration on a single implant.

Conclusions:

Bilayered scaffolds are essential for simultaneous regeneration of cartilage and bone in osteochondral tissue engineering.
Innovation in scaffold design and fabrication, particularly in materials science, is crucial for clinical success.
Further research into optimized scaffold combinations is needed to advance OA treatment.