Related Experiment Video
Updated: Jun 29, 2026
Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
Published on: March 25, 2016
Cutaneous granulomas with predominantly CD8(+) lymphocytic infiltrate in a child with severe combined
Stamatis Gregoriou1, Georgios Trimis, Christina Charissi
11st Department of Dermatology, University of Athens, Greece. stamgreg@yahoo.gr
Background:
Combined immunodeficiency disorders comprise a heterogeneous group of diseases characterized by both humoral and cell-mediated immunodeficiency. Cutaneous granulomas manifestations in children with combined immunodeficiency are rare.
Objective:
We report the case of a 6-year-old boy who presented with disseminated cutaneous granulomas and a history of multiple infections.
Methods And Results:
Laboratory evaluation revealed severe combined immunodeficiency, and deoxyribonucleic acid (DNA) analysis confirmed mutations on a gene of chromosome 19 that encodes an enzyme called Janus kinase 3 (Jak-3). Immunohistochemistry revealed expression of CD8(+) in the perivascular lymphocytic infiltrate
Conclusion:
Disseminated granulomatous lesions in children with a history of frequent infections should prompt the clinician to initiate detailed immunocompetence evaluation as they might prove to be the first manifestation of immunologic impairment.
Related Concept Videos
01:25Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
01:27Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...