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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
Published on: January 28, 2021
LDL-cholesterol lowering increases plasma apelin in isolated hypercholesterolemia
Ilker Tasci1, Gokhan Erdem, Gokhan Ozgur
1Department of Internal Medicine, Gulhane School of Medicine, Ankara, Turkey. ilkertasci@yahoo.com
Atherosclerosis
|October 11, 2008
Summary
Lowering LDL cholesterol through lifestyle changes or statins increases plasma apelin levels. This study investigated apelin
Area of Science:
- Cardiovascular Science
- Endocrinology
- Metabolic Syndrome
Background:
- Apelin, an adipokine, has known cardiovascular functions and its levels may decrease in dyslipidemia.
- The impact of hypolipidemic interventions on apelin levels requires further investigation.
Purpose of the Study:
- To determine if plasma apelin concentrations increase following hypolipidemic interventions.
- To compare the effects of therapeutic lifestyle change (TLC) and statin treatment on apelin and other biomarkers.
Main Methods:
- A study involving 134 patients with dyslipidemia, divided into TLC and rosuvastatin treatment groups.
- Measurement of plasma apelin, adiponectin, leptin, TNF-alpha, hsCRP, and insulin at baseline and post-intervention.
- Statistical analysis to assess changes in biomarkers in relation to LDL-cholesterol reduction.
Main Results:
- LDL-cholesterol reduction, achieved by either TLC or statin therapy, was associated with a significant increase in plasma apelin.
- Plasma adiponectin also increased with both interventions.
- Leptin decreased after TLC, while TNF-alpha and hsCRP decreased after statin treatment. Insulin and HOMA-IR decreased after TLC but not statin therapy.
Conclusions:
- Reduction of LDL-cholesterol, irrespective of the hypolipidemic method (TLC or statin), leads to increased plasma apelin concentrations in individuals with isolated dyslipidemia.
- Apelin may play a role in the mechanisms underlying atherosclerosis.
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