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Published on: April 14, 2010
The effects of IL-6 on CD4 T cell responses
Oliver Dienz1, Mercedes Rincon
1Department of Medicine/Immunobiology program, Given Medical Building D305, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA.
Abstract:
Cytokines have long been known to profoundly influence the adaptive immune response by determining CD4 T cell differentiation. Although IL-6 has been initially characterized as a B cell growth factor and inducer of antibody production research from our lab and others has revealed over the last years that IL-6 also plays a significant role in CD4 T cell differentiation. This review highlights the variety of ways in which IL-6 affects CD4 effector functions and how this may contribute to different types of diseases.
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