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Origin recognition complex (ORC) mediates histone 3 lysine 4 methylation through cooperation with Spp1 in

Junsuo Kan1, Lan Zou, Jingjing Zhang

  • 1Department of Biochemistry and Center for Cancer Research, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

The Journal of Biological Chemistry
|October 11, 2008
PubMed

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Histone Modification02:32

Histone Modification

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Acetylation
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Histone Modification02:32

Histone Modification

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Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
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Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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Protein Complexes with Interchangeable Parts

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