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Updated: Jun 29, 2026
11:05
Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
Oxidative stress is fundamental to hyperbaric oxygen therapy
1Department of Emergency Medicine, Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6068, USA. sthom@mail.med.upenn.edu
Journal of Applied Physiology (Bethesda, Md. : 1985)
|October 11, 2008
Summary
Hyperbaric oxygen therapy leverages reactive oxygen and nitrogen species to promote wound healing and reduce inflammation. This review explores its therapeutic mechanisms via cell signaling pathways.
Area of Science:
- Biomedical Science
- Physiology
- Cell Biology
Background:
- Reactive species of oxygen and nitrogen (RSNs) are crucial in cellular signaling.
- Hyperbaric oxygen (HBO) therapy is clinically effective for various conditions.
- Understanding RSNs' role in HBO mechanisms is key to optimizing treatment.
Purpose of the Study:
- To review advances in understanding the role of RSNs in HBO therapy.
- To organize findings around clinical conditions where HBO is effective.
- To elucidate how HBO modulates RSNs for therapeutic benefit.
Main Methods:
- Literature review of controlled clinical trials on HBO therapy.
- Analysis of studies investigating RSNs in cell signal transduction.
- Focus on pathways mediating wound healing, post-ischemic, and inflammatory injuries.
Main Results:
- Controlled trials demonstrate HBO efficacy in specific clinical scenarios.
- RSNs are integral to cell signal transduction pathways.
- HBO influences RSNs to mediate healing and reduce injury.
Conclusions:
- HBO therapy's therapeutic effects are significantly mediated by RSNs.
- Targeting RSN-mediated pathways offers a mechanism for HBO's clinical success.
- Further research into these pathways can refine HBO applications.
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