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Updated: Jun 29, 2026

Regulating Schwann Cell Growth by Nanosecond Pulsed Electric Field for Peripheral Nerve Regeneration In Vitro
Published on: May 3, 2024
ErbB receptors modulation in different types of peripheral nerve regeneration
Chiara Audisio1, Silvia Nicolino, Anna Scevola
1Department of Animal and Human Biology, Orthopaedic Department, C.T.O. Hospital, Turin, Italy.
Abstract:
ErbBs are a family of receptors involved in the trophic maintenance of Schwann cells. Little is known about their expression changes during peripheral nerve regeneration. The aim of this study was thus to investigate variations in ErbBs after end-to-end and end-to-side nerve regeneration in the rat median nerve model. Expression of ErbBs was assessed at 7, 14, and 28 days postoperatively by real-time PCR. Results showed that expression of ErbB1 and ErbB4 mRNAs was downregulated, whereas ErbB3 mRNA was upregulated. No significant changes in ErbB2 mRNA were detected. Our results suggest that ErbBs changes are involved in the molecular response to peripheral nerve injuries.
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