Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Septic shock and multiple organ failure.

E Ruokonen1, J Takala, A Kari

  • 1Department of Intensive Care, Kuopio University Hospital, Finland.

Critical Care Medicine
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of dexmedetomidine compared with midazolam for sedation in adult intensive care patients.

British journal of anaesthesia·2014
Same author

Heparin-binding protein (HBP) in critically ill patients with influenza A(H1N1) infection.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2013
Same author

Association of automated data collection and data completeness with outcomes of intensive care. A new customised model for outcome prediction.

Acta anaesthesiologica Scandinavica·2012
Same author

Corticosteroid therapy in intensive care unit patients with PCR-confirmed influenza A(H1N1) infection in Finland.

Acta anaesthesiologica Scandinavica·2011
Same author

Serum zinc in critically ill adult patients with acute respiratory failure.

Acta anaesthesiologica Scandinavica·2011
Same author

Vasopressor agents after experimental brain death: effects of dopamine and vasopressin on vitality of the small gut.

Transplantation proceedings·2010
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Attracting Emergency Medicine Graduates to Surgical Critical Care Training Programs.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Beyond a Snapshot: Tracking Family Prognostic Expectations in the ICU.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure: Beware of Potential Confounders.

Critical care medicine·2026
See all related articles

Septic shock is a significant cause of death in intensive care units (ICUs), with high mortality rates. Early deaths are often due to refractory hypotension, while later deaths result from multiple organ failure.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Pathophysiology

Background:

  • Septic shock is a life-threatening condition characterized by circulatory dysfunction and organ hypoperfusion.
  • Understanding the epidemiology and clinical course of septic shock is crucial for improving patient outcomes in intensive care settings.

Purpose of the Study:

  • To determine the incidence and mortality rates of septic shock in intensive care unit (ICU) patients.
  • To analyze the progression of multiple organ failure (MOF) in patients experiencing septic shock.

Main Methods:

  • A retrospective case survey was conducted at a tertiary care center.
  • Data from 2,469 consecutive ICU patients over two years were analyzed for septic shock frequency and mortality.
  • A subset of 1,311 patients was assessed for organ system failures at 48 hours and 4-7 days post-septic shock onset.

Related Experiment Videos

Main Results:

  • Septic shock occurred in 1.9% of ICU patients, with a 72.9% mortality rate.
  • Refractory hypotension caused 15 of 18 early deaths (within 72 hours).
  • Multiple organ failure was the primary cause of death beyond 72 hours, with a higher number of failing organ systems in non-survivors.

Conclusions:

  • Septic shock represents a major cause of mortality in ICU patients.
  • Refractory hypotension is a critical factor in early septic shock mortality.
  • Multiple organ failure emerges as the predominant cause of death in later stages of septic shock.