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Related Concept Videos

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Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Healing and relapse of duodenal ulcer during ranitidine therapy in the elderly. The RUDER Study Group.

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Related Experiment Video

Updated: Jun 29, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

[Pain palliation using unsealed radionuclides].

W U Kampen1, M Fischer

  • 1Nuklearmedizin Spitalerhof, Spitalerstrasse 8, 20095 Hamburg, Deutschland. kampen@nuklearmedizin-spitalerhof.de

Schmerz (Berlin, Germany)
|October 11, 2008
PubMed
Summary

Systemic radionuclide therapy offers a palliative, low-side-effect option for managing chronic pain from bone metastases. This complementary treatment effectively reduces pain in most breast and prostate cancer patients, though complete relief is rare.

Area of Science:

  • Oncology
  • Pain Management
  • Nuclear Medicine

Background:

  • Chronic pain is a significant distress for patients with bone metastases from malignant diseases.
  • Current treatments include WHO-scheme analgesics, surgery, radiotherapy, and systemic radionuclide therapy.
  • Systemic radionuclide therapy is suitable for patients with widespread bone metastases.

Purpose of the Study:

  • To evaluate systemic radionuclide therapy as a palliative pain treatment for bone metastases.
  • To assess its efficacy, side effect profile, and cost-effectiveness.
  • To position it as a complementary therapy within an interdisciplinary pain management approach.

Main Methods:

  • Systemic radionuclide therapy administration for palliative pain relief.

Related Experiment Videos

Last Updated: Jun 29, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

  • Assessment of pain reduction and side effects.
  • Evaluation of cost:utility ratio based on preliminary data.

    • Main Results:

    • Positive clinical effects with marked pain reduction observed in 70-80% of breast and prostate cancer patients.
    • Palliative treatment is associated with minimal severe side effects.
    • Preliminary data suggest a favorable cost:utility ratio.

    Conclusions:

    • Systemic radionuclide therapy is an effective complementary treatment for palliative pain in bone metastases.
    • It offers a low-risk, cost-effective option for patients with multilocular disease.
    • While it significantly reduces pain, most patients still require ongoing analgesic treatment.