[The mechanisms of the cytotoxic action of hyperthermia]

A review of literature on the most significant aspects of molecular and cellular effect of hyperthermia is presented. A critical evaluation of the acceptability of several hypotheses for biochemical mechanisms of cytotoxic action of hyperthermia is made. A special attention is paid to a molecular model of thermic-induced cellular death, proposed by Roti-Roti. In conclusion it is generalized that the thermic induced changes in the chromatin are those, which are involved in realization of DNA damage and which process, if not completely, at least partially in the basis of thermic induced cellular death.