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Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...

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Updated: Jun 29, 2026

Triplet Fusion Upconversion Nanocapsule Synthesis
08:36

Triplet Fusion Upconversion Nanocapsule Synthesis

Published on: September 7, 2022

Microcapsules ejecting nanosized species into the environment.

Bruno G De Geest1, Michael J McShane, Jo Demeester

  • 1Department of Pharmaceutics, Utrecht University, The Netherlands.

Journal of the American Chemical Society
|October 14, 2008
PubMed
Summary
This summary is machine-generated.

New microcapsules eject nanoparticles at speeds 800x faster than diffusion. These advanced microcarriers enable rapid transport of nanosized particles in viscous fluids, with potential uses in drug delivery and tissue engineering.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Brownian motion limits the transport of nanoparticles in fluids.
  • Efficient delivery of nanosized species is crucial for applications like drug delivery and tissue engineering.
  • Current methods for nanoparticle transport in viscous media are often slow and inefficient.

Purpose of the Study:

  • To report the development of microcapsules capable of ejecting nanoparticles.
  • To quantify the ejection speed of nanoparticles from these microcapsules in an aqueous environment.
  • To explore the potential applications of these microcapsule systems in various scientific fields.

Main Methods:

  • Synthesis and characterization of novel microcapsules.
  • Experimental setup to measure nanoparticle ejection velocity in water.
  • Comparative analysis of nanoparticle speed versus Brownian diffusion.

Main Results:

  • Microcapsules successfully eject nanoparticles into the surrounding environment.
  • The ejected nanoparticles travel at speeds approximately 800-fold faster than their Brownian diffusion rate.
  • Demonstrated feasibility of rapid nanoparticle translocation in aqueous media.

Conclusions:

  • Developed microcapsules provide a mechanism for accelerated nanoparticle transport.
  • This technology offers a promising solution for overcoming diffusion limitations in nanoscale transport.
  • Potential applications include enhanced drug delivery systems and advanced tissue engineering scaffolds.