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Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
Natural Treg in autoimmune diabetes: all present and correct?
1University of Birmingham Medical School, Medical Research Council Centre for Immune Regulation, Birmingham, B15 2TT, UK. L.S.Walker@bham.ac.uk
Background:
The critical role for regulatory T cells (Treg) in suppressing autoimmune pathology is now well recognised. However, the extent to which defects in regulation can be blamed for the onset of diseases like type 1 diabetes is not clear.
Objective:
To collate the available data from mouse models and from studies of type 1 diabetes patients, with a view to understanding the status of the natural Treg compartment in this disease setting.
Results/Conclusion:
Available evidence suggests that natural Treg are not under-represented in type 1 diabetes, and that Treg function is only likely to be suboptimal in a subset of patients. Emerging therapeutic strategies that attempt to exploit our knowledge of Treg biology to restore effective immune regulation in type I diabetes are discussed.
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