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Updated: Jun 29, 2026
06:26
Micro-Colony Forming Unit Assay for Efficacy Evaluation of Vaccines Against Tuberculosis
Published on: July 28, 2023
How could we have better vaccines against tuberculosis?
1University of Notre Dame, Eck Center for Global Health & Infectious Disease, Department of Biological Sciences, Notre Dame, IN-46556, USA. pramodgiri75@gmail.com
Expert Opinion on Biological Therapy
|October 14, 2008
Summary
Tuberculosis (TB) remains a major global health threat. New vaccine strategies are crucial as the current Bacillus Calmette-Guérin vaccine offers limited protection against pulmonary TB in adults.
Area of Science:
- Immunology
- Infectious Diseases
- Vaccinology
Background:
- Tuberculosis (TB) is the second deadliest infectious disease globally, with over 9 million new cases in 2006.
- Approximately one-third of the world's population is infected with the TB bacillus.
- An estimated 1.7 million deaths occurred in 2006, highlighting the urgent need for effective control measures.
Purpose of the Study:
- To review recent advancements in TB immunology.
- To explore potential strategies for developing next-generation TB vaccines.
Main Methods:
- Systematic review of scientific literature.
- Analysis of published research in various journals.
Main Results:
- The current Bacillus Calmette-Guérin (BCG) vaccine, developed over 85 years ago, shows limited efficacy in preventing pulmonary TB in adolescents and adults.
- BCG is effective in preventing severe forms of TB in early childhood.
Conclusions:
- Evolving TB strains necessitate the development of novel vaccines to control the pandemic.
- Cutting-edge vaccine technologies and strategies, such as prime-boost vaccination, are under active investigation worldwide.
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
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Mode of...
Causative Organism
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Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
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Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...