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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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Endocarditis III: Medical Management

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Related Experiment Video

Updated: Jun 29, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Current challenges in treating MRSA: what are the options?

Natasha V D V Ratnaraja1, Peter M Hawkey

  • 1Department of Microbiology, Sandwell and West Birmingham NHS Trust, Birmingham, UK.

Expert Review of Anti-Infective Therapy
|October 14, 2008
PubMed
Summary

Methicillin-resistant Staphylococcus aureus (MRSA) presents a growing global health challenge. This review covers MRSA epidemiology, control, and current/emerging antimicrobial treatments.

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Last Updated: Jun 29, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Increasing prevalence of methicillin resistance in Staphylococcus aureus (MRSA) poses a significant global health threat.
  • Community-associated MRSA (CA-MRSA) presents unique epidemiological and natural history challenges.
  • Effective control strategies for MRSA are urgently needed.

Purpose of the Study:

  • To review the challenges associated with the global rise of MRSA.
  • To discuss the epidemiology and natural history of CA-MRSA.
  • To examine current and developing antimicrobial treatments for MRSA.

Main Methods:

  • Literature review of scientific articles and clinical studies on MRSA.
  • Analysis of epidemiological data and treatment outcomes.
  • Evaluation of antimicrobial agents against MRSA.

Main Results:

  • MRSA, particularly CA-MRSA, exhibits complex epidemiology and challenging control dynamics.
  • A range of antimicrobial agents are available for MRSA treatment, with new agents under development.
  • The optimal therapeutic role for novel antimicrobial agents is yet to be fully established.

Conclusions:

  • Addressing the global challenge of MRSA requires a comprehensive understanding of its epidemiology and effective control measures.
  • Current and emerging antimicrobial therapies offer options, but strategic implementation is key.
  • Further research is needed to define the place of new agents in MRSA treatment regimens.