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Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications

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[Lanthanum carbonate in clinical practice].

V Torregrosa Prats¹

¹Servicio de Nefrologia, Unidad Trasplante Renal, Hospital Clinic, Barcelona, Spain.

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia

|October 14, 2008

Summary

Lanthanum carbonate effectively controls serum phosphate in chronic kidney disease patients for up to 5 years. This phosphate binder is well-tolerated, with rare gastrointestinal issues and no hypercalcemia, improving patient compliance.

Area of Science:

Nephrology
Pharmacology
Biochemistry

Background:

Lanthanum carbonate is a rare earth element studied for intestinal phosphate binding due to low solubility.
It is used in monotherapy for managing hyperphosphatemia in chronic kidney disease (CKD).

Purpose of the Study:

To evaluate the efficacy and safety of lanthanum carbonate as a phosphate binder.
To assess its impact on serum phosphate levels and potential side effects in CKD patients.

Main Methods:

Clinical trials were conducted to assess lanthanum carbonate's effectiveness.
Adverse effects, drug interactions, and pharmacokinetic profiles were analyzed.

Main Results:

Serum phosphate controlled in ~70% of patients at 5 years without hypercalcemia.

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Low incidence of gastrointestinal disturbances (6%) observed.

No significant impact on fat-soluble vitamins or interactions with common medications, except for quinolones, tetracyclines, and doxycycline.

Conclusions:

Lanthanum carbonate is a potent and well-tolerated phosphate binder for CKD patients.
Chewable formulations and reduced daily tablet count may improve patient compliance.
Effective phosphate control is achievable with minimal adverse effects.