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Related Experiment Videos

Haemodialysis studies with dichloroacetate.

S H Curry1, A Lorenz, G N Henderson

  • 1College of Pharmacy, University of Florida, Gainesville 32610.

European Journal of Clinical Pharmacology
|January 1, 1991
PubMed
Summary

Hemodialysis significantly increases dichloroacetate (DCA) clearance by 60% but does not affect its volume of distribution. DCA remains safe and effective for hemodialysis patients needing treatment for lactic acidosis.

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Area of Science:

  • Pharmacology
  • Nephrology
  • Clinical Therapeutics

Background:

  • End-stage renal failure patients often require hemodialysis.
  • Dichloroacetate (DCA) is a potential therapeutic agent, but its use in dialysis patients requires pharmacokinetic evaluation.

Purpose of the Study:

  • To investigate the pharmacokinetics and pharmacodynamics of dichloroacetate (DCA) in patients undergoing hemodialysis.
  • To assess the impact of dialysis timing on DCA's distribution, elimination, and metabolic effects (lactate and glucose).

Main Methods:

  • Seven end-stage renal failure patients on thrice-weekly hemodialysis received DCA (50 mg/kg IV infusion over 30 min).
  • DCA was administered on consecutive days, with one administration coinciding with a dialysis session.
  • Pharmacokinetic parameters (volume of distribution, elimination rate constants) and metabolic effects (blood glucose, lactate) were assessed relative to dialysis timing.

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Main Results:

  • Hemodialysis increased DCA plasma clearance by approximately 60% without altering its apparent volume of distribution.
  • DCA's maximal lactate-lowering effect was not reduced by dialysis, though its duration was slightly decreased.
  • No significant alterations in blood glucose levels or adverse drug effects were observed.

Conclusions:

  • Dialysis enhances the plasma clearance of DCA in patients with end-stage renal failure.
  • DCA demonstrates safety and efficacy in hemodialysis patients, supporting its use for conditions like lactic acidosis.