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Deep venous thrombosis and inferior vena cava agenesis causing double crush sciatic neuropathy in Behçet's disease

Murat Kara1, Levent Ozçakar, Güneş Eken

  • 1Department of Physical Medicine and Rehabilitation, Hacettepe University Medical School, Ankara, Turkey.

Joint Bone Spine
|October 14, 2008
PubMed

Insights

This case study details a young man with Behçet's disease experiencing multiple vascular and neurological complications, including deep vein thrombosis and nerve compression. It highlights a rare combination of conditions in a single patient with this rare disease.

Area of Science:

  • Vascular Medicine
  • Neurology
  • Rheumatology

Background:

  • Behçet's disease is a rare multisystem inflammatory disorder.
  • Vascular complications, including deep vein thrombosis (DVT), are known manifestations.
  • Neurological involvement can occur but is less common.

Observation:

  • An 18-year-old male with Behçet's disease presented with right femoral and popliteal deep venous thrombosis.
  • This led to secondary right sciatic nerve injury, drop foot, and Achilles tendon tightness.
  • Further investigation revealed an agenetic inferior vena cava and epidural vein dilatations causing lumbar nerve root compression.

Findings:

  • The patient exhibited an exceptionally complex presentation of Behçet's disease complications.
  • This includes concurrent DVT, neurological deficits, congenital vascular anomalies, and spinal venous abnormalities.
  • This constellation of findings is unprecedented in the literature for Behçet's disease.

Implications:

  • This case underscores the diverse and severe vascular and neurological potential of Behçet's disease.
  • It highlights the importance of comprehensive diagnostic workups in complex presentations.
  • Further research may elucidate shared pathophysiological mechanisms between Behçet's disease and congenital vascular anomalies.

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