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Related Concept Videos

Chromosome Duplication02:05

Chromosome Duplication

The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
Centrosome Duplication02:25

Centrosome Duplication

The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
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Centrosome Duplication02:25

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The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
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Gene Duplication and Divergence02:37

Gene Duplication and Divergence

The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
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Polytene Chromosomes02:04

Polytene Chromosomes

Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also regularly...

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A Mechanical Construction to Enhance the Stability and Safety of Lifting and Thrusting Manipulation of Acupuncture
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[Thumb duplication].

G Dautel1, S Barbary

  • 1Unité fonctionnelle de chirurgie de la main de l'enfant, service de chirurgie infantile orthopédique, hôpital de Brabois-Enfants, CHU de Nancy, 5, allée du Morvan, 54500 Vandoeuvre-les-Nancy, France. gillesdautel@mac.com

Chirurgie De La Main
|October 14, 2008
PubMed
Summary
This summary is machine-generated.

Thumb duplication, a common congenital abnormality, is treated surgically by reconstructing or removing duplicates. Surgical outcomes depend on factors like deviation and stability, with functional but imperfect results typical.

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Area of Science:

  • Orthopedics
  • Congenital Abnormalities
  • Hand Surgery

Background:

  • Thumb duplication is a frequent congenital abnormality requiring surgical intervention.
  • Wassel classification categorizes thumb duplication into seven types based on skeletal division, with Type IV being most common.
  • Surgical outcomes are influenced by angular deviation, joint stability, and duplicate size.

Purpose of the Study:

  • To outline surgical strategies for thumb duplication based on Wassel classification.
  • To identify factors affecting surgical results in thumb duplication repair.
  • To discuss the functional and cosmetic outcomes of surgical thumb duplication treatment.

Main Methods:

  • Surgical reconstruction techniques vary by duplication type (Wassel classification).
  • Distal types (I, II) involve fusion of duplicates (Bilhaut-Cloquet procedure).
  • Proximal types involve retaining one duplicate, removing the other, and performing ligament reconstruction, osteotomy, and soft tissue augmentation.

Main Results:

  • Surgical treatment aims for acceptable cosmetic and functional outcomes.
  • Specific procedures like the Bilhaut-Cloquet procedure are used for distal duplications.
  • Proximal duplications require additional procedures for stability and alignment.

Conclusions:

  • Surgical management of thumb duplication yields satisfactory results but rarely perfect.
  • Patients may experience reduced range of motion at the interphalangeal (IP) and/or metacarpophalangeal (MP) joints post-surgery.
  • Optimal surgical strategy depends on the specific type and characteristics of the thumb duplication.