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Related Experiment Video

Updated: Jun 29, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Right ventricular pump function after cardiac resynchronization therapy: a strain imaging study.

Erwan Donal¹, Hélène Thibault, Cyrille Bergerot

¹Service de cardiologie, hôpital Pontchaillou, Rennes, France.

Archives of Cardiovascular Diseases

|October 14, 2008

Summary

This summary is machine-generated.

Cardiac resynchronization therapy (CRT) improves right ventricular (RV) function in heart failure patients, even before RV dimensions change. This study used strain analysis to show early RV functional improvements after CRT.

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Area of Science:

Cardiology
Heart Failure Research
Medical Device Technology

Background:

Cardiac resynchronization therapy (CRT) is known to improve left ventricular (LV) function in congestive heart failure (CHF) patients.
The impact of CRT on right ventricular (RV) function remains less understood.

Purpose of the Study:

To evaluate the early effects of CRT on RV function.
Utilized myocardial strain analysis for precise RV function assessment.

Main Methods:

Studied 50 CHF patients (NYHA class III/IV, LVEF < 35%, QRS > 120 ms) pre- and post-CRT (3 months).
Assessed RV dimensions, tricuspid annulus plane systolic excursion, V(s), and lateral wall strain.
Quantified RV mechanical dyssynchrony using time-to-peak strain differences.

Main Results:

Significant improvement in LV ejection fraction (LVEF) and decrease in LV end-diastolic volumes observed in patients with baseline LV dyssynchrony.
RV dimensions showed no significant change.
Early improvement in RV function noted, with increased V(s) and RV lateral wall strain (P<0.01).

Conclusions:

CRT significantly enhances RV function in CHF patients within three months.
RV functional improvement occurs independently of significant changes in RV dimensions.
RV strain improvement correlated with baseline RV dyssynchrony and septal lead placement.