Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and Radiographic Survival Rates of the Arthrex Univers VaultLock Uncemented Central-Peg All-Polyethylene Glenoid Component in Anatomic Total Shoulder Arthroplasty at 2- and 5-Years Postoperatively.

Journal of shoulder and elbow surgery·2026
Same author

Statin therapy is not associated with inferior postoperative outcomes after arthroscopic rotator cuff repair: a systematic review and meta-analysis.

Journal of shoulder and elbow surgery·2026
Same author

Revisiting Intranasal Salmon Calcitonin: Historical Osteoporosis Evidence and a Potential Role in Acute Orthopaedic Pain Management.

JBJS reviews·2026
Same author

External hinged fixation vs. internal joint stabilization for elbow instability: a systematic review and meta-analysis of functional outcomes and surgical complications.

JSES reviews, reports, and techniques·2026
Same author

Surgical treatment of post-traumatic elbow stiffness in pediatric patients: a systematic review and meta-analysis.

JSES reviews, reports, and techniques·2026
Same author

Outcomes of transosseous suture-cable repair for lesser tuberosity osteotomy in stemless anatomic total shoulder arthroplasty: a retrospective case series.

Journal of shoulder and elbow surgery·2026

Related Experiment Video

Updated: Jun 29, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Tissue engineering with meniscus cells derived from surgical debris.

B M Baker1, A S Nathan, G Russell Huffman

  • 1McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, United States.

Osteoarthritis and Cartilage
|October 14, 2008
PubMed
Summary

Surgical debris yields potent cells for engineered meniscus tissue. These meniscus-derived cells (MDCs) can form functional fibrocartilaginous matrix, showing promise for knee repair, even in older patients.

More Related Videos

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
08:30

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Published on: April 30, 2014

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

Related Experiment Videos

Last Updated: Jun 29, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
08:30

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Published on: April 30, 2014

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Orthopedic Surgery

Background:

  • Meniscus injuries often require tissue resection, leading to impaired knee function.
  • Current treatments fail to restore normal load transmission.
  • Tissue engineering offers a potential solution for meniscus repair and regeneration.

Purpose of the Study:

  • To investigate the potential of meniscus-derived cells (MDCs) from surgical debris as a cell source for engineered meniscus constructs.
  • To assess the influence of donor age and disease status on MDC-derived tissue formation.
  • To evaluate the characteristics of engineered meniscus constructs using MDCs.

Main Methods:

  • MDCs were isolated from waste meniscus tissue of 10 human donors (ages 18-84).
  • Cells were expanded and seeded onto nanofibrous scaffolds in defined media.
  • Engineered constructs were cultured for 10 weeks and evaluated for mechanical, biochemical, and histological properties.

Main Results:

  • Cells from all donors contributed to construct development, increasing biochemical content and mechanical properties.
  • Significant donor-to-donor variability was observed, but not correlated with age or disease.
  • High collagen deposition correlated with enhanced tensile properties, reaching up to 40 MPa.

Conclusions:

  • Meniscus-derived cells from surgical debris represent a viable cell source for tissue engineering functional meniscus constructs.
  • Robust tissue formation is achievable with MDCs from middle-aged and elderly donors.
  • This highlights the potential of autologous cell-based therapies for meniscus repair.