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Updated: Jun 29, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Published on: March 26, 2019
Neuro-immune crosstalk in CNS diseases
M Kerschensteiner1, E Meinl, R Hohlfeld
1Institute of Clinical Neuroimmunology, Ludwig-Maximilians University Munich, Marchioninistr. 17, 81377 Munich, Germany. Martin.Kerschensteiner@med.uni-muenchen.de
Immune cells in the central nervous system (CNS) can harm or protect neurons. The outcome of this neuro-immune crosstalk depends on the balance of destructive versus protective molecules released by immune cells.
Area of Science:
- Neuroscience
- Immunology
- Cell Biology
Background:
- Immune cell infiltration into the central nervous system (CNS) is common in neurological diseases.
- Immune cells and neurons communicate via shared mediators in the CNS.
- The impact of this neuro-immune crosstalk is context-dependent.
Purpose of the Study:
- To explore the dual role of immune cells in the CNS.
- To investigate the molecular mechanisms underlying neuroprotection and neurodestruction mediated by immune cells.
Main Methods:
- Review of existing literature on neuro-immune interactions in neurological diseases.
- Analysis of molecular mediators released by immune cells in CNS lesions.
Main Results:
- Inflammatory reactions in the CNS can cause tissue injury.
- Emerging evidence shows inflammatory cells can promote neuroprotection and repair.
- Immune cells release both neurodestructive and neuroprotective molecules in CNS lesions.
Conclusions:
- The net effect of neuro-immune crosstalk is determined by the balance between destructive and protective factors.
- Understanding this balance is crucial for developing therapeutic strategies for neurological diseases.
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08:47Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
Published on: May 8, 2016
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