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Cost-Efficient Transcriptomic-Based Drug Screening
Published on: February 23, 2024
Implications of pharmacogenomics for drug development
Randal J Kirk1, Jeffrey L Hung, Scott R Horner
1Third Security, LLC, 1881 Grove Avenue, Radford, VA 24141, USA. randal.krk@gmail.com
Experimental Biology and Medicine (Maywood, N.J.)
|October 14, 2008
Summary
Pharmacogenomics (PGx) is widely used in drug development and increasingly in medicine. Challenges remain for broader adoption, including education and regulatory hurdles.
Area of Science:
- Pharmacogenomics
- Genetics
- Drug Development
Background:
- Pharmacogenomics (PGx) is integral to modern drug development.
- Increasingly, PGx guides clinical medicine with genetic biomarker-based drug indications.
Observation:
- The history and tools of PGx in research, clinical trials, and practice are reviewed.
- Economic, regulatory, and technological factors driving PGx adoption are examined.
Findings:
- Current barriers to widespread PGx implementation include pharmaceutical industry practices, clinical education gaps, statistical methodology needs, and intellectual property issues.
Implications:
- Addressing these impediments is crucial for fully realizing the benefits of pharmacogenomics in healthcare.
- Enhanced understanding and integration of PGx can personalize medicine and improve patient outcomes.
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