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Related Experiment Video

Updated: May 1, 2026

Assessing the Secretory Capacity of Pancreatic Acinar Cells
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A rapid, endoscopic exocrine pancreatic function test and the Lundh test: a comparative study.

Nanna M Jensen1, Steen Larsen

  • 1Department of Gastroenterology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark. nmj@dadlnet.dk

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [Et Al.]
|October 14, 2008
PubMed
Summary

A new endoscopic secretin stimulation test (ESST) safely assesses exocrine pancreatic function. Combining lipase and bicarbonate measurements, it offers a rapid, easy, and useful diagnostic tool for chronic pancreatitis.

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Area of Science:

  • Gastroenterology
  • Diagnostic Medicine
  • Pancreatic Physiology

Background:

  • Early diagnosis of chronic pancreatitis is challenging due to normal morphological tests.
  • Current exocrine pancreatic function tests are often time-consuming and cumbersome.

Purpose of the Study:

  • To evaluate a novel endoscopic secretin stimulation test (ESST) for assessing exocrine pancreatic function.
  • To compare the ESST with the established Lundh meal test.

Main Methods:

  • ESST involved intravenous secretin administration followed by duodenal aspiration.
  • Measured concentrations of lipase, bicarbonate, and elastase in aspirates.
  • Used Lundh test lipase concentrations as a reference in patients.

Main Results:

  • ESST showed significant differences in lipase and bicarbonate concentrations between patients with varying degrees of exocrine pancreatic dysfunction.
  • Strong correlations were found between ESST lipase/bicarbonate and Lundh test lipase.
  • The test demonstrated no significant difference between healthy volunteers and patients with normal exocrine pancreatic function (NEPF).

Conclusions:

  • The endoscopic secretin stimulation test (ESST) is a safe and effective method for evaluating exocrine pancreatic function.
  • Combining lipase and bicarbonate measurements in ESST provides a rapid, easy, and useful diagnostic approach.