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Refractive errors and strabismus in Asian patients with Down syndrome
1Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea.
Eye (London, England)
|October 14, 2008
Summary
Refractive errors and strabismus patterns in Asian patients with Down syndrome vary with age. Esotropia and hyperopia were more prevalent, with myopia and exotropia increasing or decreasing respectively with age.
Area of Science:
- Ophthalmology
- Genetics
- Pediatrics
Background:
- Down syndrome is associated with a higher incidence of ocular abnormalities.
- Understanding refractive error and strabismus patterns is crucial for early intervention in Down syndrome patients.
Purpose of the Study:
- To investigate the prevalence and age-related patterns of refractive errors and strabismus in Korean patients with Down syndrome.
- To compare findings with previously reported data.
Main Methods:
- A cohort of 261 Korean patients with Down syndrome underwent comprehensive ophthalmologic examinations.
- Patients were categorized into four age groups for analysis.
- Refractive errors and strabismus were defined using standardized criteria.
Main Results:
- Hyperopia (46.5%) was more common than myopia (40.1%), with myopia prevalence increasing and hyperopia decreasing with age.
- Astigmatism was highly prevalent (66.8%), and anisometropia (29.7%) correlated significantly with age and astigmatism.
- Esotropia (22.1%) was twice as common as exotropia (10.5%), with esotropia prevalence increasing and exotropia decreasing with age. Nystagmus was observed in 29.1%.
Conclusions:
- Esotropia and hyperopia are more common in Asian patients with Down syndrome than exotropia and myopia, respectively.
- The study revealed a higher prevalence of exotropia and astigmatism than previously reported in this population.
- Age-dependent patterns were observed for myopia, hyperopia, esotropia, and exotropia.
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